|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We previously reported mutations in the "hot spots" between exons 5-8 of the p53 gene in adrenocortical carcinomas but not in adenomas.
|
8855814 |
1996 |
|
Adrenocortical carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
We found a statistically significant correlation between the expression of p53, p21, Ki67 and the differential diagnosis of adrenal cortical adenoma and adrenocortical carcinoma (for proteins: p53 p=0.010, for p21 p=0.010, for Ki67 p<0.001).
|
18393131 |
2008 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Virilizing adrenocortical carcinoma in a child with Turner syndrome and somatic TP53 gene mutation.
|
19701813 |
2010 |
|
Adrenocortical carcinoma
|
0.800 |
PosttranslationalModification
|
disease |
BEFREE |
To investigate the role of coding region mutation and promoter hypermethylation of TP53 in adrenocortical cancer formation.
|
15922892 |
2005 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that mutational inactivation of the p53 gene occurs in a minority (20%) of sporadic adrenocortical carcinomas and that these mutations constitute a late event in the multi-step process of malignant transformation.
|
8509216 |
1993 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
There were marked organ-specific differences in the mean age at which carriers of p53 germline mutations present with neoplastic disease: 5 years for adrenocortical carcinomas, 16 years for sarcomas, 25 years for brain tumors, 37 years for breast cancer, and almost 50 years for lung cancer.
|
9006316 |
1997 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The tetramerization domain for wild-type p53 (p53tet-wt) and a p53 mutant, R337H (p53tet-R337H), associated with adrenocortical carcinoma (ACC) in children, can be converted from the soluble native state to amyloid-like fibrils under certain conditions.
|
12634062 |
2003 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The low rate of cure of adrenocortical carcinomas (ACC) in children and adults is related to germ line TP53 mutation, late diagnosis, incomplete surgical resection, and lack of an efficient adjunctive therapy.
|
29372993 |
2017 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The genetic predisposition to adrenocortical cancer in children has been well established in the Li-Fraumeni and Beckewith-Wiedeman syndromes due to germline p53 mutation located at 17p13 and dysregulation of the imprinted IGF-2 locus at 11p15, respectively.
|
16001332 |
2005 |
|
Adrenocortical carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
The finding that only a minority of adrenocortical tumors with 17p13 LOH had either a VNTR1 LOH or a TP53 mutation indicates that TP53 might not be the only or major tumor suppressor gene at 17p13 involved in adrenocortical cancer progression.
|
17289876 |
2007 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The authors here present a family with pR337P mutation in TP53 gene who had a child with acute lymphoblastic leukemia (ALL) and associated adrenocortical carcinoma as a case 1 and his cousin with brain tumor as a case 2.
|
20426520 |
2010 |
|
Adrenocortical carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
The adrenocortical carcinoma showed positive staining for both p53 and cyclin D1 and a high Ki-67 index of 60%.
|
28095038 |
2017 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Simultaneous adrenocortical carcinoma and ganglioneuroblastoma in a child with Turner syndrome and germline p53 mutation.
|
9598730 |
1998 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Rhabdomyosarcoma, osteosarcoma, and adrenocortical carcinoma in a child with a germline p53 mutation.
|
15390294 |
2004 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Recently, a characteristic TP53 mutation at codon 337 (R337H) has been identified in the germline of children with adrenocortical carcinoma in Southern Brazil.
|
15878142 |
2005 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Prevalence of germline TP53 mutations in a prospective series of unselected patients with adrenocortical carcinoma.
|
23175693 |
2013 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the TP53 codon 72 polymorphism could be associated with susceptibility for adrenocortical cancer in the examined Polish patients.
|
16786124 |
2006 |
|
Adrenocortical carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
One adrenocortical carcinoma tissue showed very high p53 protein content (3000 pg/mg cytosolic protein).
|
9972675 |
1998 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the TP53 gene are frequent in adrenocortical carcinomas and might be used as a marker of malignancy.
|
11454518 |
2001 |
|
Adrenocortical carcinoma
|
0.800 |
Biomarker
|
disease |
CTD_human |
Mutational analyses of epidermal growth factor receptor and downstream pathways in adrenocortical carcinoma.
|
23585556 |
2013 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
More rarely, it occurs in the Li-Fraumeni syndrome, caused by a p53 germline mutation, in which markedly early-onset BC is found in association with brain tumors, sarcomas, leukemia, lymphoma, malignant melanoma, and adrenal cortical carcinoma.
|
18086272 |
2008 |
|
Adrenocortical carcinoma
|
0.800 |
SusceptibilityMutation
|
disease |
ORPHANET |
Molecular markers and the pathogenesis of adrenocortical cancer.
|
18515740 |
2008 |
|
Adrenocortical carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Less common genotype variants of TP53 polymorphisms are associated with poor outcome in adult patients with adrenocortical carcinoma.
|
24566897 |
2014 |
|
Adrenocortical carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
It may be reasonable for children with adrenocortical carcinoma to be candidates for germline TP53 analysis.
|
7966399 |
1994 |
|
Adrenocortical carcinoma
|
0.800 |
Biomarker
|
disease |
CTD_human |
Integrated genomic characterization of adrenocortical carcinoma.
|
24747642 |
2014 |